MassIVE MSV000090807

Partial Public PXD038456

Structure of an endogenous mycobacterial MCE lipid transporter

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Description

Mycobacterium tuberculosis, the causative agent of tuberculosis, is one of the leading causes of death due to infectious disease. The Mammalian Cell Entry proteins are essential virulence factors during infection and are thought to facilitate the import of nutrients across the highly complex mycobacterial cell envelope. We purified an endogenous Mammalian Cell Entry complex from the model mycobacterium, Mycobacterium smegmatis, identified components of the Mce1 protein complex using mass spectrometry, and determined its structure using single-particle cryo-electron microscopy and AlphaFold2. This entry contains the mass spectrometry raw files and search results for the LC-MS analysis of the purified complex. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Mycobacterium smegmatis ; Mammalian Cell Entry complex

Contact

Principal Investigators:
(in alphabetical order) 		Beatrix Ueberheide, New York University Grossman School of Medicine, USA
Submitting User: Trixi
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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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