MassIVE MSV000094245

Partial Public PXD050403

Immuno-Oncologic Profiling by Stage-Dependent Transcriptome and Proteome Analyses of Spontaneously Regressing Canine Cutaneous Histiocytoma

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Description

Canine cutaneous histiocytoma (CCH) is a tumor originating from dermal Langerhans cells, especially affecting young dogs. The common spontaneous regression of CCH makes it an interesting model in comparative oncology research. Here, we asked which specific immuno-oncological dynamics underlie spontaneous regression of CCH on mRNA and protein levels. QuantSeq 3' mRNA sequencing with functional overrepresentation analysis and an nCounter RNA hybridization assay were employed on CCH samples representing three different tumor stages. Additionally, samples were subjected to matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). [doi:10.25345/C5RB6WD06] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Canine Cutaneous Histiocytoma ; Mass Spectrometry Imaging ; Proteomics

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Principal Investigators:
(in alphabetical order) 		Benjamin-Florian Hempel, Freie University Berlin, Germany
Submitting User: benjamin_hempel
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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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