MassIVE MSV000094754

Complete Public PXD052262

YjbH contributes to S. aureus skin pathology and immune response through Agr-mediated alpha-toxin regulation

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Description

Staphylococcus aureus is a global health threat that can cause a multitude of diseases in many different areas of the body and is the leading cause of skin infections. This bacterium can produce a variety of proteins that contribute to virulence and disease progression. These virulence factors include alpha-hemolysin (Hla), which can kill many different cell types in the human body. In this study, we identified a new protein that contributes to Hla production, YjbH. It does so by controlling the activity of the Accessory Gene Regulator (Agr), a major player in the modulation of proteins produced in the bacterium. We demonstrate that without YjbH, S. aureus cultures produce less Hla, and this is corroborated during infection. Accordingly, when YjbH is present, tissue damage is greater during infection than when it is absent. Overall, our study sheds light on the complex regulation involved in virulence factor production by S. aureus and its ability to cause a wide range of diseases. [doi:10.25345/C50863H2G] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: YjbH ; alpha-toxin regulatioin

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Principal Investigators:
(in alphabetical order) 		Jeffrey L. Bose, University of Kansas Medical Center, USA
Submitting User: KUMC_Prot
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