MassIVE MSV000095873

Partial Public PXD055894

The UGT2B17 metabolic pathway as a key determinant of liver homeostasis: evidence from the hepatic proteome of individuals naturally deficient in UGT2B17

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Description

One of the most crucial pathways involved in the metabolism and detoxification of drugs and endobiotics is the glucuronidation process, primarily occurring in the liver. This pathway is catalyzed by glycosyltransferases comprising 22 enzymes such as UGT2B17, which is entirely absent in a large proportion of the population, due to complete gene deletion. We defined the impact of a UGT2B17 deficiency on the proteome of normal human liver tissues by data-independent acquisition mass spectrometry. [doi:10.25345/C58W38D75] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: DIAnn ; Liver proteomics ; Glycosyltransferase ; UGT2B17 ; Germline gene deletion

Contact

Principal Investigators:
(in alphabetical order) 		Chantal Guillemette, CHU de Quebec Research Center - Universite Laval, Canada
Submitting User: microu

Publications

Rouleau M, Schwab M, Klein K, Tremmel R, Haag M, Schaeffeler E, Guillemette C.
The liver proteome of individuals with a natural UGT2B17 complete deficiency.
Sci Rep. 2025 Feb 14;15(1):5458. Epub 2025 Feb 14.

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