MassIVE MSV000092056

Partial Public PXD042551

Extracellular matrix orchestration of tissue remodelling during chronic colitis

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Description

Ulcerative colitis is a debilitating and recurrent condition with significant co-morbidities including risk of developing cancer and that is associated with extensive tissue remodeling that is both a consequence and mediator of disease progression. Here, label-free mass spectrometry was used to characterise extracellular matrix remodelling in a murine model of colitis. Unique proteomic profiles of the extracellular matrix landscape distinguished inflamed from matched-normal colon tissue thus identifying pre- and pathological colitic states that were predominantly differentiated by expression of proteoglycans. Network maps derived from this dataset highlighted a central role for matrisomal proteins in epithelial-stromal interactions and identified orchestrating nodes that could be exploited in selection of therapeutic targets. [doi:10.25345/C5MW28Q9W] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Inflammatory Bowel Diseases ; Extracellular Matrix ; Proteoglycans ; Quantitative Proteomics ; Data-Independent Acquisition (DIA)

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Principal Investigators:
(in alphabetical order) 		Birgit Schilling, Buck Institute, USA
Submitting User: JoannaBons
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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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