MassIVE MSV000093838

Partial Public PXD048469

Uncovering missing glycans and unexpected fragments with pGlycoNovo: a full-range Y-ion dynamic searching strategy for site-specific glycosylation analysis across species

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Description

Precision mapping of glycans at the site-specific level using mass spectrometry data has emerged as a crucial approach for glycan discovery in modern glycoproteomics and glycobiology. However, the extensive diversity of glycan compositions within and across species far surpasses the capacity of existing software databases. Consequently, the identification of glycans not included in the database or lacking prior compositional knowledge during large-scale glycoproteomic analyses poses a significant challenge. Here, we present pGlycoNovo, a software platform for analyzing intact glycopeptides featuring rare glycan attachments within the pGlyco3 software environment. [doi:10.25345/C56H4D19T] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: pGlyco ; Glycosylation ; De novo

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Principal Investigators:
(in alphabetical order) 		Weiqian Cao, Institutes of Biomedical Sciences,Fudan University, China
Submitting User: Mingqiliu
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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
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