MassIVE MSV000083265

Partial Public PXD012122

Human corneocyte cross-linked envelopes are comprised of a multitude of proteins

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Description

The cornified outer layer of epidermis (stratum corneum) is our major extra-pulmonary barrier to the environment. This layer results from a well-orchestrated program of terminal differentiation producing corneocytes filled primarily with keratin intermediate filaments tightly connected by disulfide bonding. This cytoskeleton is interconnected to an isopeptide cross-linked protein envelope at the cell periphery stabilized by transglutaminase cross-linking.The envelope serves as a scaffold for deposition of the lipid barrier containing w-OH-ceramides secreted from inside the maturing keratinocytes.That defects in the transglutaminase gene TGM1 are a major cause of autosomal recessive congenital ichthyosis testifies to the importance of proper envelope formation for barrier function. [doi:10.25345/C5X61B] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: corneocyte

Contact

Principal Investigators:
(in alphabetical order) 		Robert H. Rice, Department of Environmental Toxicology, University of California, Davis, United States
Submitting User: brettsp1

Publications

Karim N, Phinney BS, Salemi M, Wu PW, Naeem M, Rice RH.
Human stratum corneum proteomics reveals cross-linking of a broad spectrum of proteins in cornified envelopes.
Exp. Dermatol. 2019 May;28(5):618-622.

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