The aims of this study were to study ESPs to improve understanding of parasite-host interactions and to support the discovery of novel diagnostic or therapeutic targets. We used tandem mass-spectrometry to characterize the secretome of adult P. kellicotti flukes and to compare ESPs released during in vitro culture with parasite cyst fluid proteins (CFPs) which correspond to ESPs released by adult flukes in vivo. We also compared these results to the global proteome of soluble, somatic protein (SSP) extracts of whole adult flukes.
[doi:10.25345/C5T14TT10]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Secretome ; Excretome ; nano LC-MS/MS ; soluble somatic protein ; biomarker
Principal Investigators: (in alphabetical order) |
Peter U. Fischer, Washington University School of Medicine, USA |
Submitting User: | jimmalone |
Di Maggio LS, Curtis KC, Erdmann-Gilmore P, Sprung RSW, Townsend RR, Weil GJ, Fischer PU.
Comparative proteomics of adult Paragonimus kellicotti excretion/secretion products released in vitro or present in the lung cyst nodule.
PLoS Negl Trop Dis. 2022 Aug 17;16(8):e0010679. Epub 2022 Aug 17.
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