MassIVE MSV000087014

Complete Public PXD024586

Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes

Description

We examined the phagosome and lysosome proteome to determine the effects of type I IFN and IFITM3 on phagosome proteolysis. Phagosomes were isolated from IFNbeta-treated macrophages using magnetic latex beads, and lysosomes were isolated using iron dextran. [doi:10.25345/C5V51C] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: bacterial infection, IFITM3, Listeria monocytogenes, type I interferon

Contact

Principal Investigators:
(in alphabetical order)
John Brumell, The Hospital for Sick Children, Canada
Submitting User: jonstgermain
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Experimental Design
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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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