MassIVE MSV000083750

Partial Public PXD013721

A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development-2

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Description

The senescence-associated secretory phenotype (SASP) has recently emerged as both a driver of -- and promising therapeutic target for -- a multitude of chronic age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically monitored by the secretion of a few proteins, has been greatly underappreciated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present SASP Atlas, a comprehensive proteomic database of SASPs driven by multiple inducers of senescence in different human cell types. While there are common elements among all the SASPs we have documented so far, we discovered distinct senescence inducer- and cell type-specific secretory proteins. In all cases, the SASPs are comprised of hundreds of unique proteins secreted as both soluble proteins (sSASP) and exosomes (eSASP) with distinct and novel protein profiles. This resource will aid in identifying the proteins that drive senescence-associated phenotypes and provide comprehensive catalogs of potential senescence biomarkers that can be used to assess the burden and the originating stimuli and type of senescent cells in vivo. [doi:10.25345/C5RK87] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: senescence ; data-independent acquisition ; secretome ; sasp ; senescence-associated secretory phenotype ; aging ; biomarker

Contact

Principal Investigators:
(in alphabetical order) 		Birgit Schilling, The Buck Institute for Research on Aging, USA
Submitting User: nbasisty
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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
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