MassIVE MSV000084034

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Metabolomics Workbench ST000386 - GNPS - Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer

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Description

SS = Sigma sample and is used as a quality control The first set (ADC1) used for biomarker development consisted of serum and plasma samples obtained from 52 stages I to IV NSCLC adenocarcinoma patients (52 plasma and 49 serum), and 31 healthy controls (31 pairs of serum and plasma) for a total of 163 samples. This set was regarded as the training set for biomarker discovery and classifier development. A second, independent case control study (ADC2) consisting of serum and plasma samples collected from 43 stage I to IV NSCLC adenocarcinoma patients and 43 healthy controls (total 172 samples) was used as an independent test set for biomarker evaluation. A limitation of this study is the relatively small sample size for each cohort 52 cases, 31 controls for ADC1, and 43 cases and 43 controls for ADC2 because patient variability can be a big factor in smaller studies. [doi:10.25345/C5H94S] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: blood ; serum ; GCMS ; lung cancer

Contact

Principal Investigators:
(in alphabetical order) 		Oliver Fiehn, University of California, Davis, N/A
Submitting User: aaksenov
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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.