This dataset consists of 18 raw DDA MS files and associated peak lists and results files, acquired on timsTOF Pro2 mass spectrometer operated in Data Dependent Acquisition-PASEF (Parallel accumulation-serial fragmentation) mode. It also consists of 18 raw DIA MS files acquired in Data Independent-PASEF mode on timsTOF Pro2 mass spectrometer.
Samples were generated by Juline Poirson. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Analysis was performed by Cassandra Wong and Juline Poirson.
The files are associated with a manuscript submitted for publication by Juline Poirson et al. The main goal of this paper was to establish a synthetic proteome-scale platform to identify human proteins that promote degradation or stabilization of a target protein in a proximity-dependent manner.
Mikko Taipale is the corresponding author of the manuscript (mikko.taipale@utoronto.ca); Anne-Claude Gingras should be contacted for questions on this dataset (gingras@lunenfeld.ca)
This submission is associated with 3 Supplementary Files (in addition to this README file)
Table 1 describes the composition of this dataset
Table 2 lists all the peptide identification evidence (as per iProphet)
Table 3 lists the protein intensity values
[doi:10.25345/C5H41JX90]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Targeted protein degradation ; Targeted protein stabilization ; FBXL12 ; FBXL15 ; BCR-ABL1
Principal Investigators: (in alphabetical order) |
Anne-Claude Gingras, LTRI, Canada |
Submitting User: | gingraslab |
Poirson J, Cho H, Dhillon A, Haider S, Imrit AZ, Lam MHY, Alerasool N, Lacoste J, Mizan L, Wong C, Gingras AC, Schramek D, Taipale M.
Proteome-scale discovery of protein degradation and stabilization effectors.
Nature. 2024 Apr;628(8009):878-886. Epub 2024 Mar 20.
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Experimental Design | ||
Conditions:
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Identification Results | ||
Proteins (Human, Remapped):
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Proteins (Reported):
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Peptides:
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Variant Peptides:
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PSMs:
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Quantification Results | ||
Differential Proteins:
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Quantified Proteins:
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Browse Dataset Files | Browse Results |
FTP Download Link (click to copy):
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