K562 cell lysate was digested with trypsin, dephosphorylated with lambda phosphatase, and treated in an in vitro kinase reaction with Axl, Mer or Tyro3 kinase, alongside a control reaction for each that contained no kinase. Samples were phosphoenriched with the SMOAC approach (TiO2 and FeNTA) and analyzed on an Orbitrap-Velos. Peptides were identified using PEAKS Studio X Pro.
[doi:10.25345/C5513V612]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: kinase ; phosphopeptide ; AXL ; MERTK ; TYRO3 ; KALIP
Principal Investigators: (in alphabetical order) |
Laurie Parker, University of Minnesota, USA |
Submitting User: | llparker |
Widstrom NE, Andrianov GV, Heier JL, Heier C, Karanicolas J, Parker LL.
Novel Substrate Prediction for the TAM Family of RTKs Using Phosphoproteomics and Structure-Based Modeling.
ACS Chem Biol. 2024 Jan 19;19(1):117-128. Epub 2023 Dec 30.
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