MADD is a multifunctional protein regulating activation and localization of small GTP-binding proteins RAB3 and RAB27, MAPK-signaling and cell survival. Polymorphisms in MADD locus have been associated with glycemic traits, but patients with bi-allelic variants in MADD manifest complex syndrome affecting nervous, endocrine, exocrine and hematological systems. We created relevant cell lines for AP-MS and BioID to examine the protein interactome of MADD to clarify how this mutation could leading the syndrome.
[doi:10.25345/C54X54T1V]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: MADD
Principal Investigators: (in alphabetical order) |
Markku Varjosalo, University of Helsinki, Finland |
Submitting User: | XIOLIU |
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Owner | Reanalyses | |
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