ApoE knockout mice were exposed to intermittent hypoxia and hypercapnia (treatment) or room air (controls). Perturbations in the gut microbiome were profiled longitudinally using LC-MS/MS to study the impact of treatment on the gut metabolome over the course of the day. Samples were collected after 6 days of exposure to conditions. Samples were collected every 4 hours for 24hrs (6 timepoints) to examine circadian rhythm dynamics.
[doi:10.25345/C5X97N]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: sleep apnea ; circadian rhythm ; fecal ; microbiome ; metabolome ; hypoxia ; cardiovascular ; mouse
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Amir Zarrinpar, University of California San Diego, USA |
Submitting User: | callaban |
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