MassIVE MSV000092543

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N-terminal acetylation for identification of cleavage sites on immunoprecipitated PrP

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Description

In-gel N-terminal acetylation of immunoprecipitated prion protein for identification of cleavage sites. Mouse expressing either WT or mutant (S3) form of PrP were used in this study. Three replicates from single brains were included in this experiment. [doi:10.25345/C5JH3DC8J] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Prion protein ; Acetylation ; N-terminomics ; Cleavage sites ; Immunoprecipitation

Contact

Principal Investigators:
(in alphabetical order) 		Olivier Julien, University of Alberta, Canada
Submitting User: julienlab

Publications

Gomez-Cardona E, Eskandari-Sedighi G, Fahlman R, Westaway D, Julien O.
Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo.
ACS Chem Neurosci. 2024 Jan 3;15(1):134-146. Epub 2023 Dec 14.

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