MassIVE MSV000100069

Partial Public PXD071457

RBM10 modulation of circRNAs in lung cancer

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Description

Circular RNAs (circRNAs) are emerging regulators in cancer biology, yet the mechanisms underlying their biogenesis remain incompletely defined. RBM10, a splicing regulator frequently mutated in lung adenocarcinoma (LUAD), modulates RNA processing, but its involvement in circRNA regulation has not been characterized. Proteomic analyses further identified RBM10 SF3B1 interaction as a key upstream event governing circHIPK3 biogenesis. [doi:10.25345/C5M03ZB09] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: backsplicing ; spliceosome ; immunoprecipitation ; DatasetType:Proteomics

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Principal Investigators:
(in alphabetical order) 		Pedro P Medina Vico, Universidad de Granada, Spain
Submitting User: anamatiagonzalez
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