MassIVE MSV000092704

Partial Public PXD044678

Loss of function cancer associated mutations in the EIF4G2 non canonical translation initiation factor

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Description

Tumor cells often exploit the protein translation machinery, resulting in enhanced protein expression essential for tumor growth. Since canonical translation initiation is often suppressed due to cell stress in the tumor microenvironment, non-canonical translation initiation mechanisms become particularly important for shaping the tumor proteome. EIF4G2 is a non-canonical translation initiation factor that mediates internal ribosome entry site (IRES) and upstream open reading frame (uORF) dependent initiation mechanisms, which can be used to modulate protein expression in cancer. Here we explored the contribution of EIF4G2 to cancer by screening the COSMIC database for EIF4G2 somatic mutations in cancer patients. [doi:10.25345/C5GQ6RC5T] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Cancer ; translation initiation ; EIF4G2

Contact

Principal Investigators:
(in alphabetical order) 		Adi Kimchi, Weizmann Institute of Science, Israel
Submitting User: ylevinwis
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