MassIVE MSV000098442

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Effect of the PET microplastics on pancreas - in vivo study on pig

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Description

Microplastics are a relatively newly discovered environmental hazard that can contribute to the disruption of many physiological processes in the organism. There is evidence that they affect the physiology of the pancreas, but research is still very limited. Therefore, the aim of the study was to determine the effects of PET microplastics on the global proteomic profile of the porcine pancreas using LC-MS/MS analysis. The pigs were treated with a low (0.1 g/day) or a high dose (1 g/day) of PET microplastics for 4 weeks. The analysis revealed that PET microplastics affected protein expression in a dose-dependent manner - the low dose affected the abundance of 7 proteins, while the high dose of 17. [doi:10.25345/C57W67J6W] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: pancreas ; microplastics ; pig ; glucose metabolism ; DatasetType:Proteomics

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Principal Investigators:
(in alphabetical order) 		Robert Stryinski, University of Warmia and Mazury in Olsztyn, Poland
Submitting User: robertstr
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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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