MassIVE MSV000086129

Partial Public

Functionally selective activation of the dopamine receptor D2 is mirrored by the protein expression profiles

Description

Shotgun proteomics dataset investigating the influence of five balanced (quinpirole, haloperidol, sulpiride) and functionally selective (BM138, MS308) dopamine receptor D2 (D2R) ligands on the proteome of HEK293T cells transfected with the short isoform of D2R. Note: In the raw dataset, BM138 is mislabeled as BM308, and MS308 is labeled as MS308P2. [doi:10.25345/C5F767] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: untargeted proteomics ; protein expression profiling ; receptor-ligand interaction ; functional selectivity ; dopamine receptor D2 ; quinpirole ; haloperidol ; sulpiride

Contact

Principal Investigators:
(in alphabetical order)
Dr. Thomas Kislinger, Princess Margaret Cancer Centre, Canada
Submitting User: TKislinger
Number of Files:
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Owner Reanalyses
Experimental Design
    Conditions:
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Identification Results
    Proteins (Human, Remapped):
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Quantification Results
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Number of distinct conditions across all analyses (original submission and reanalyses) associated with this dataset.

Distinct condition labels are counted across all files submitted in the "Metadata" category having a "Condition" column in this dataset.

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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct protein accessions reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct unmodified peptide sequences reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct peptide sequences (including modified variants or peptidoforms) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Total number of peptide-spectrum matches (i.e. spectrum identifications) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.