MassIVE MSV000088562

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GNPS Dereplication of Natural Bioactive Products from Leaves of Stryphnodendron pulcherrimum

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Description

Stryphnodendron pulcherrimum is a species known to have a high content of tannins. Accordingly, its preparations are used in southern Para, Brazil, for their anti-inflammatory and antimicrobial activities, but so far, its chemical profile composition remains essentially unknown. We herein describe the compounds present in a hydro-acetonic extract from S. pulcherrimum leaves as revealed by dereplication via ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry. The data were combined with spectral organization, spectral matching through the Global Natural Products Social platform, in silico annotation and taxonomical ponderation. Several types of phenolic compounds were identified such as gallic acids, flavan-3-ols and flavone-like compounds. From these, 5 have been recently reported by our group, whereas 44 are reported here for the first time in this tree species, and 41 (out of 49) for this genus. The results highlight the possible role of Stryphnodendron pulcherrimum as a renewable source for natural bioactive products with potential pharmaceutical applications. [doi:10.25345/C5VK38] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Stryphnodendron ; Phenolic compounds ; Dereplication ; Molecular network ; Flavonoids

Contact

Principal Investigators:
(in alphabetical order) 		Milton Silva, Federal University of Para, Brazil
Paulo Wender Portal Gomes, Federal University of Para, Brazil
Submitting User: wendergomes

Publications

Paulo Wender P. Gomes, Luis Quirós-Guerrero, Consuelo Silva, Sônia Pamplona, Jean A Boutin, Marcos Eberlin, Jean-Luc Wolfender, Milton Silva.
Feature-Based Molecular Network-Guided Dereplication of Natural Bioactive Products from Leaves of Stryphnodendron pulcherrimum (Willd.) Hochr.
Metabolites. 2021 Apr 29;11(5):281. doi: 10.3390/metabo11050281.

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