The aim of this study is to identify candidate genes modulating platelet reactivity in aspirin-treated cardiovascular patients using an integrative network-based approach. Platelet reactivity was assessed in 110 cardiovascular patients treated with aspirin 100mg/d by aggregometry using several agonists. Patients with extreme high or low PR were selected for further analysis. Data derived from quantitative proteomic of platelets and platelet sub-cellular fractions, as well as from transcriptomic analysis were integrated with a network biology approach.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Platelets ; secretory granules ; releasate ; cardiovascular patients ; network biology ; aspirin ; high platelet reactivity
Principal Investigators: (in alphabetical order) |
Pierre Fontana, Pierre Fontana, MD, PhD Division of Angiology and Heamostasis University Hospitals of Geneva Rue Gabrielle-Perret-Gentil 4 1205 Geneva Switzerland +41 22 372 97 49, N/A |
Submitting User: | ccms |
Zufferey A, Ibberson M, Reny JL, Nolli S, Schvartz D, Docquier M, Xenarios I, Sanchez JC, Fontana P.
New molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach.
Hum. Genet. 2016 Apr;135(4):403-414. Epub 2016 Feb 16.
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