MassIVE MSV000079384

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GNPS_Euphorbia amygdaloides ssp. semiperfoliata (Corsican Euphorbiaceae plant)

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Description

Euphorbia amygdaloides ssp. semiperfoliata, LC-MSn analysis of AcOEt plant extract, and 12 references MS2 spectra of diterpene esters. Fragmentation behavior of diterpene esters (jatrophane type) had been studied by multiple stage mass spectrometry. The AcOEt showed very potent antiviral activity (against chikungunya virus and HIV). See papers: http://dx.doi.org/10.1016/j.chroma.2015.09.092 http://dx.doi.org/10.1021/np500271u http://dx.doi.org/10.1016/j.fitote.2015.06.021 [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Euphorbia ; diterpene ester

Contact

Principal Investigators:
(in alphabetical order) 		Litaudon/Touboul
Submitting User: lfnothias

Publications

Nothias-Scaglia LF, Dumontet V, Neyts J, Roussi F, Costa J, Leyssen P, Litaudon M, Paolini J.
LC-MS²-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity.
Fitoterapia. Epub 2015 Jul 4.

Nothias-Scaglia LF, Retailleau P, Paolini J, Pannecouque C, Neyts J, Dumontet V, Roussi F, Leyssen P, Costa J, Litaudon M.
Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead.
J. Nat. Prod. 2014 Jun 27;77(6):1505-12. Epub 2014 Jun 13.

Nothias-Scaglia LF, Schmitz-Afonso I, Renucci F, Roussi F, Touboul D, Costa J, Litaudon M, Paolini J.
Insights on profiling of phorbol, deoxyphorbol, ingenol and jatrophane diterpene esters by high performance liquid chromatography coupled to multiple stage mass spectrometry.
J Chromatogr A. Epub 2015 Oct 13.

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GNPS content goes here (MSV000079384 [task=19de8e6f41e942eea9a34304bf7d85fc])
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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct protein accessions reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct unmodified peptide sequences reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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