MassIVE MSV000098374

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Unraveling Metabolic Alterations in Avian Influenza Exposed Individuals A Non Targeted Metabolomics Approach

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Description

Avian influenza poses a continuous public health threat, particularly to individuals with occupational exposure to poultry such as farm workers, live animal market employees, and processing plant staff. To investigate the systemic metabolic effects of such exposure, we applied an untargeted liquid chromatography mass spectrometry (LC MS) based metabolomics approach to analyze serum samples from occupationally exposed individuals and healthy controls. Multivariate statistical analysis revealed clear separation between the two groups, with stable clustering of quality control samples indicating high analytical reproducibility. Pathway enrichment and topology analyses identified several significantly altered metabolic pathways in the exposed group, most notably alanine, aspartate and glutamate metabolism and tryptophan metabolism, both of which are closely linked to immune regulation, energy metabolism, and host-pathogen interactions. In addition, lipidomic profiling revealed a pronounced increase in lysophosphatidylcholine (LPC) levels and a concurrent decrease in phosphatidylcholine (PC) species in exposed individuals, suggesting inflammation-associated lipid remodeling. These findings provide novel insights into the metabolic disruptions associated with avian influenza exposure and highlight potential serum biomarkers for early detection and health risk assessment in high risk occupational populations. [doi:10.25345/C5BZ61N1Z] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: metabolomics ; DatasetType:Proteomics

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Principal Investigators:
(in alphabetical order) 		maoshuoqin, China capital medical school, China
Submitting User: maoshuoqin
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