MassIVE MSV000096022

Partial Public PXD056487

Human skeletal muscle bioenergetic pathways are altered in Alzheimers disease

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Description

Skeletal muscle involvement in Alzheimers disease (AD) is supported by reduced lean mass, motor function and mitochondrial respiration in early disease. However, no one has comprehensively assessed molecular alterations in muscle that could underly these findings. We used two human muscle types, quadriceps (n=81) and temporalis (n=66), to compare the skeletal muscle proteome between individuals with and without AD (AD: n= 54 temporalis, 44 quadriceps; controls: n=27 temporalis, 22 quadriceps). We compared the effects of diagnosis between muscle types and in APOE4 carriers versus APOE4 non-carriers. Mitochondrial pathways in skeletal muscle are downregulated in AD. These effects are greatest in the temporalis compared to the quadriceps and in APOE4 carriers compared to APOE4 non-carriers. [doi:10.25345/C5PC2TM84] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Alzheimers disease ; skeletal muscle ; DIA proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Jill K Morris, University of Kansas Medical Center, USA
Submitting User: KUMC_Prot

Publications

Chelsea N. Johnson, Mara R. Evans, Anneka E. Blankenship, Casey S. John, Michaella J. Rekowski, Michael P. Washburn, Andy Phan, Cynthia M. Gouvion, Mohammad Haeri, Russell H. Swerdlow, Paige C. Geiger, Jill K. Morris.
Human skeletal muscle mitochondrial pathways are impacted by a neuropathologic diagnosis of Alzheimer's disease.
Neurobiology of Disease, 210, 2025, doi.org/10.1016/j.nbd.2025.106916.

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