MassIVE MSV000098636

Partial Public PXD066552

MesoMap: Mesoscale proximity labeling of chromatin for small molecule mechanism of action

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Description

Mesoscale proximity labeling of chromatin is used to understand the impact that inhibitors have on chromatin structure and dynamics. We use uMap proximity labeling, distributed throughout chromatin to study how HDAC inhibition alters interactions. We then apply this approach to de-orphan a high throughput screening hit SR1815. We show that SR1815 is a kinase inhibitor that hits CLK proteins and alters RNA splicing. [doi:10.25345/C5ZK5604C] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: chromatin, proximity labeling ; DatasetType:Proteomics

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Principal Investigators:
(in alphabetical order) 		Ciaran Seath, University of Florida, USA
Submitting User: cseath
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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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