MassIVE MSV000088003

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Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis

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Description

Non-alcoholic fatty liver disease is now considered the most common form of chronic liver disease. It is a complex metabolic disease that silently progresses into non-alcoholic steatohepatitis (NASH). In fact, NASH is the tipping point for pericellular fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Despite being a complex metabolic disease, identification of the metabolic readout that functions in metabolic pathway perpetuation for HCC progression from NASH is still incompletely understood. With the aid of LC MS/MS this study unveiled the metabolic fingerprint of NASH and HCC-NASH patients and it illustrates a detailed map for the most predominant reprogrammed metabolic pathways that target HCC development from NASH. https://doi.org/10.3390/ijms24010210 [doi:10.25345/C5DZ7J] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: NASH ; HCC ; Cancer ; Metabolomics

Contact

Principal Investigators:
(in alphabetical order) 		Sameh Magdeldin, Proteomics and metabolomics unit, Basic research department, Children's Cancer Hospital, 57357 Cairo, (CCHE-57357), Egypt
Submitting User: alianwar

Publications

Ahmed EA, El-Derany MO, Anwar AM, Saied EM, Magdeldin S.
Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis.
Int J Mol Sci. Epub 2022 Dec 22.

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