MassIVE MSV000089926

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Synphilin-1 upregulates RBL2 expression and causes a G0/G1 phase cell cycle arrest in the neurons

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Description

Synphilin-1, a major component of Lewy bodies in the brain of Parkinsons disease (PD) patients, is a cytoplasmic protein that interacts with alpha-synuclein and is suggested to have cytoprotective effects in the neuronal cells. alpha-Synuclein overexpression induced re-entry of the neuronal cells into the cell cycle, which is associated with neuronal death. However, the role of synphilin-1 in cell cycle progression remains unelucidated. Here, we aimed at investigating the role of synphilin-1 in cell cycle progression using human embryonic kidney (HEK) 293 cells, human neuroblastoma SH-SY5Y cells, and post-mortem brains of PD patients. [doi:10.25345/C50Z71153] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: alpha-synuclein ; cell cycle ; RBL2 ; synphilin-1 ; Parkinsons disease

Contact

Principal Investigators:
(in alphabetical order) 		Gwang Lee, Department of Physiology, Ajou University School of Medicine, 206, World cup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea
Submitting User: juyeon4444

Publications

Kim SG, Li J, Hwang JS, Hassan MAU, Sim YE, Lee JY, Mo JS, Kim MO, Lee G, Park S.
Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin.
J Nanobiotechnology. 2025 May 14;23(1):345. Epub 2025 May 14.

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