MassIVE MSV000086901

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Global proteomic profiles of meningioma tissues reveal proteogenomic subtypes

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Description

Fresh-frozen meningioma tissues of varying WHO grades were analyzed by shotgun DDA proteomics. The proteomic profiles were compared and reflected a set of new clinical subtypes derived from genomic, epigenomic and transcriptomic data which improved risk stratification. [doi:10.25345/C52B77] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: proteogenomics ; meningioma ; clinical subtyping

Contact

Principal Investigators:
(in alphabetical order) 		Dr. Gelareh Zadeh, Toronto Western Hospital, Canada
Dr. Thomas Kislinger, Princess Margaret Cancer Centre, Canada
Submitting User: TKislinger
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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct protein accessions reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct unmodified peptide sequences reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct peptide sequences (including modified variants or peptidoforms) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Total number of peptide-spectrum matches (i.e. spectrum identifications) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.