MassIVE MSV000096440

Partial Public PXD057972

Extracellular vesicles from immortalised human amniotic epithelial cells reduce hepatic fibrosis in mice with Steatohepatitis and Hepatocellular Carcinoma

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Description

evaluated the preclinical efficacy of immortalised hAEC EVs in a murine model of MASH and HCC. This model captures the histological, metabolic and immunological dysregulation seen in human MASH within 12 weeks and progression to HCC by 24 weeks. In this study we evaluated the effect of ihAEC EVs on steatosis, fibrosis, inflammation and liver regeneration and further characterized both protein and miRNA cargo to better elucidate the potential mechanisms of ihAEC EVs action in the setting of experimental MASLD/MASH. [doi:10.25345/C5R49GN1X] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: stem cells ; Extracellular vesicles ; fibrosis ; DatasetType:Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		David Greening, Baker Heart & Diabetes Institute, Australia
Submitting User: dwgree
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Distinct condition labels are counted across all files submitted in the "Metadata" category having a "Condition" column in this dataset.

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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

Distinct replicate labels are counted across all files submitted in the "Metadata" category having a "BioReplicate" or "Replicate" column in this dataset.

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Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct protein accessions reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct unmodified peptide sequences reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct peptide sequences (including modified variants or peptidoforms) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Total number of peptide-spectrum matches (i.e. spectrum identifications) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.