MassIVE MSV000095489

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Pilot Study on Differential Urine Proteomic Profile of Subjects with Community Acquired Acute Kidney Injury Who Recover Versus Those Who Do Not Recover Completely at 4 months after Hospital Discharge

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Description

Community acquired acute kidney injury (CAAKI) is a sudden structural damage and loss of kidney function in otherwise healthy individuals outside of hospital settings having high morbidity and mortality rates worldwide. Long-term sequelae of AKI involve an associated risk of progression to chronic kidney disease (CKD). Serum creatinine (SCr) the currently used clinical parameter for diagnosing AKI varies greatly with age, gender, diet and muscle mass. In the present study, we investigated the difference in urinary proteomic profile of subjects that recovered (R) and incompletely recovered (IR) from CAAKI, 4 months after hospital discharge. This study helped in identifying potential proteins and associated pathways that are either upregulated or downregulated at the time of hospital discharge in incompletely recovered CAAKI patients that can be further investigated to check for their exact role in the disease progression or repair. [doi:10.25345/C51C1TS83] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Community acquired acute kidney injury, proteomic, renal outcome, LCMS

Contact

Principal Investigators:
(in alphabetical order) 		Dr. Ashok Kumar Yadav, Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh, India
Submitting User: mails2sahok
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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct protein accessions reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct peptide sequences (including modified variants or peptidoforms) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Total number of peptide-spectrum matches (i.e. spectrum identifications) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.