Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by maternal mutation and paternal imprinting of the gene encoding UBE3A, an E3 ubiquitin ligase. Although several potential target proteins of UBE3A have been reported, how these proteins regulate neuronal development remains unclear. We performed a large-scale quantitative proteomic analysis using stable-isotope labeling of amino acids in mammals (SILAM) on mice with maternal Ube3a mutation.
[doi:10.25345/C51618]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: UBE3A SILAM autophagy
Principal Investigators: (in alphabetical order) |
Lujian Liao, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, China |
Submitting User: | TingtingWang |
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