MassIVE MSV000094339

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Comparative multi-omic analysis of fallopian tube fimbria from BRCA mutation carriers and control women

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Description

Integrated transcriptomic, epigenomic, and proteomic analysis of histologically normal fallopian tubes (FTs) fimbria from BRCA mutant carriers and controls. This study was undertaken to test the hypothesis that there are molecular alterations in FTs from BRCA mutant carriers that contribute to field cancerization and high-grade serous risk. We address the limitations of prior molecular profiling studies of BRCA mutant FTs by controlling for covariates known to influence the molecular and cellular landscape of the FT. [doi:10.25345/C5M32NN08] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: multi-omics ; fallopian tube fimbria ; ovarian cancer ; FFPE ; BRCA

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Principal Investigators:
(in alphabetical order) 		Jarrod Marto, DFCI, USA
Submitting User: Martolab
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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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