MassIVE MSV000081157

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Novel Sarcopenia-related Alterations in Sarcomeric Protein Post-translational Modifications in Skeletal Muscles Identified by Top-down Proteomics

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Description

Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a significant cause of morbidity in the elderly and is a major burden on health care systems. Unfortunately, the underlying molecular mechanisms in sarcopenia remain poorly understood. Herein, we utilized top-down proteomics to elucidate sarcopenia-related changes in the fast- and slow-twitch skeletal muscles of aging rats with a focus on the sarcomeric proteome, which includes both myofilament and Z-disc proteins--the proteins that constitute the contractile apparatuses. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Aging ; Sarcopenia ; Skeletal Muscle ; Sarcomere ; Top-down Proteomics ; Post-translational Modifications

Contact

Principal Investigators:
(in alphabetical order) 		Ying Ge, University of Wisconsin-Madison, United States of America
Submitting User: zgregorich
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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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