Cells expressing mutant huntingtin were treated in triplicate with serum-free DMEM with vehicle (Q111SST) or serum-free DMEM with one of 4 protective compounds (Cyproheptadine, Loxapine, Diacylglycerol Kinase Inhibitor II, Meclizine) for 24 hours. Wild type cells were also treated with serum-free DMEM with vehicle (Q7SST) as an additional control for 24 hours. We examined the compounds' proteomic and some phosphoproteomic effects on the cells using shotgun proteomics.
[doi:10.25345/C5XT2X]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: omics ; compounds ; integration
Principal Investigators: (in alphabetical order) |
Ernest Fraenkel, Massachusetts Institute of Technology, USA |
Submitting User: | nlpm |
Patel-Murray NL, Adam M, Huynh N, Wassie BT, Milani P, Fraenkel E.
A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules.
Sci Rep. 2020 Jan 22;10(1):954. Epub 2020 Jan 22.
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