We identified 967 proteins among 75 serum samples from patients with BC. Among these, 39 proteins were altered in serum samples at diagnosis, between progressors and non-progressors. Among these, 4 proteins were further altered when the progressors developed distant metastasis. In addition, within progressors, 20 proteins were altered in serum collected at diagnosis versus at the onset of metastasis. Pathway analysis showed that these proteins encoded pathways that describe metastasis, including epithelial mesenchymal transition and focal adhesion that are hallmarks of metastatic cascade.
[doi:10.25345/C5FT8DW3X]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Serum ; Breast Cancer
Principal Investigators: (in alphabetical order) |
Sung Yun Jung, Baylor College of Medicine, United States |
Submitting User: | syjung |
Kaur J, Jung SY, Austdal M, Arun AK, Helland T, Mellgren G, Lende TH, Janssen EAM, Søiland H, Aneja R.
Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients.
Clin Proteomics. 2024 Jul 29;21(1):52. Epub 2024 Jul 29.
Number of Files: | |
Total Size: | |
Spectra: | |
Subscribers: | |
Owner | Reanalyses | |
---|---|---|
Experimental Design | ||
Conditions:
|
||
Biological Replicates:
|
||
Technical Replicates:
|
||
Identification Results | ||
Proteins (Human, Remapped):
|
||
Proteins (Reported):
|
||
Peptides:
|
||
Variant Peptides:
|
||
PSMs:
|
||
Quantification Results | ||
Differential Proteins:
|
||
Quantified Proteins:
|
||
Browse Dataset Files | |
FTP Download Link (click to copy):
|