MassIVE MSV000087624

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Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors

Description

We identified certain members of the gut microbiota associated with a lower tumor burden in mouse models of colorectal cancer (CRC). Orally applied, a mix of four Clostridiales strains (CC4) prevented and even successfully treated CRC as a stand-alone therapy. [doi:10.25345/C5R82V] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Clostridia's

Contact

Principal Investigators:
(in alphabetical order)
Michael Scharl, University Hospital Zurich, Switzerland
Submitting User: Ymorsy

Publications

Montalban-Arques A, Katkeviciute E, Busenhart P, Bircher A, Wirbel J, Zeller G, Morsy Y, Borsig L, Glaus Garzon JF, Müller A, Arnold IC, Artola-Boran M, Krauthammer M, Sintsova A, Zamboni N, Leventhal GE, Berchtold L, de Wouters T, Rogler G, Baebler K, Schwarzfischer M, Hering L, Olivares-Rivas I, Atrott K, Gottier C, Lang S, Boyman O, Fritsch R, Manz MG, Spalinger MR, Scharl M.
Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors.
Cell Host Microbe. Epub 2021 08 25.

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