MassIVE MSV000091570

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IDR-Targeting Compounds Suppress HPV Genome Replication via Disruption of Phospho-BRD4 Association with DNA Damage Response Factors

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Description

Sample name abbreviation is below. Cell State: Prol for proliferation, Diff for differentiation Compound (cpd) treatment: DMSO for DMSO-only treatment, 14 or 90 for compound pNPS14 or pNPS90 treatment BRD4-L IP: L1, L2, and L3 for anti-BRD4-L IP samples 1, 2, and 3 BRD4-S IP: S1, S2, and S3 for anti-BRD4-S IP samples 1, 2, and 3 IgG IP: Ig1, Ig2, and Ig3 for IgG IP samples 1, 2, and 3 Sample ID vs. sample name is listed below. 967246 / Prol_DMSO_L1, 967247 / Prol_DMSO_L2, 967248 / Prol_DMSO_L3 967249 / Prol_14_L1, 967250 / Prol_14_L2, 967251 / Prol_14_L3 967252 / Prol_10_L1, 967253 / Prol_10_L2, 967254 / Prol_10_L3 967255 / Prol_DMSO_S1, 967256 / Prol_DMSO_S2, 967257 / Prol_DMSO_S3 967258 / Prol_14_S1, 967259 / Prol_14_S2, 967260 / Prol_14_S3 967261 / Prol_10_S1, 967262 / Prol_10_S2, 967263 / Prol_10_S3 967264 / Diff_DMSO_L1, 967265 / Diff_DMSO_L2, 967266 / Diff_DMSO_L3 967267 / Diff_14_L1, 967268 / Diff_14_L2, 967269 / Diff_14_L3 967270 / Diff_10_L1, 967271 / Diff_10_L2, 967272 / Diff_10_L3 967273 / Diff_DMSO_S1, 967274 / Diff_DMSO_S2, 967275 / Diff_DMSO_S3 967276 / Diff_14_S1, 967277 / Diff_14_S2, 967278 / Diff_14_S3 967279 / Diff_10_S1, 967280 / Diff_10_S2, 967281 / Diff_10_S3 967282 / Prol_DMSO_Ig1, 967283 / Prol_DMSO_Ig2, 967284 / Prol_DMSO_Ig3 967285 / Diff_DMSO_Ig1, 967286 / Diff_DMSO_Ig2, 967287 / Diff_DMSO_Ig3 [doi:10.25345/C5JH3DC4M] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: BRD4 ; BET ; HPV ; small compounds ; PPI inhibitors

Contact

Principal Investigators:
(in alphabetical order) 		Cheng-Ming Chiang, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, USA
Submitting User: alemoff

Publications

Wu, S.-Y., Lai, H.T., Banerjee, N.S., Ma, Z., Santana, J.F., Wei, S., Liu, X., Zhang, M., Zhan, J., Chen, H., Posner, B., Chen, Y., Price, D.H., Chow, L.T., Zhou, J., & Chiang, C.-M.
IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors.
https://doi.org/10.1016/j.molcel.2023.11.022.

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