MassIVE MSV000087049

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Truncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways

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Description

We employed isobaric labeled peptides to do bottom-up proteomics to quantify both non-enriched total peptides and enriched phospho-peptides obtained from hearts of control mice expressing wild-type cardiac troponin I and transgenic mice expressing the truncated N-terminal cardiac troponin I. [doi:10.25345/C5Q80S] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Sarcomeres ; Paxillin ; Cytoskeleton ; Integrin ; Heart ; Mouse

Contact

Principal Investigators:
(in alphabetical order) 		R. John Solaro, University of Illinois-Chicago, USA
Submitting User: cmwarren_8

Publications

Warren CM, Halas M, Goldspink PH, Feng HZ, Herren AW, Wolska BM, de Tombe PP, Jin JP, Solaro RJ.
Truncation of the N-terminus of cardiac troponin I initiates adaptive remodeling of the myocardial proteosome via phosphorylation of mechano-sensitive signaling pathways.
Mol Cell Biochem. 2022 Jun;477(6):1803-1815. Epub 2022 Mar 22.

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