This submission is associated with a paper by Hesketh et al. that identifies the GATOR-Rag GTPase pathway as a negative regulator of mTORC1 activation by lysosome-derived amino acids.
[doi:10.25345/C5CS98]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: affinity purification ; BioID ; proximity-dependent biotinylation ; proximity interaction ; lysosome ; nutrient sensing ; membrane trafficking ; mTOR signaling ; mTORC1 ; HOPS complex
Principal Investigators: (in alphabetical order) |
Anne-Claude Gingras, LTRI, Canada |
Submitting User: | gingraslab |
Hesketh GG, Papazotos F, Pawling J, Rajendran D, Knight JDR, Martinez S, Taipale M, Schramek D, Dennis JW, Gingras AC.
The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.
Science. 2020 Oct 16;370(6514):351-356.
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