MassIVE MSV000080706

Imported Reanalysis Dataset Public PXD002057

Proteomic analysis identifies novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy

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Description

Resistance to Human Epidermal Growth Factor Receptor (HER)-targeted cancer therapies appear to be occurring via common pathways, despite differences in their mechanism of action. This suggests that combination therapies targeting alternative pathways will be needed to overcome resistance. We have used a global proteomics approach to identify common signaling nodes that are required for driving HER2-independent resistance mechanisms to the pan-HER family kinase inhibitors AZD8931 and lapatinib. A novel set of epithelial–to-mesenchymal transition (EMT) associated proteins linked to resistance to pan-HER family targeted therapy was identified. We demonstrate that a sub-set of these genes are predictive of prognosis within the ERBB2 subtype of breast cancers and are worthy of further study in the context of preventing resistance to anti-HER family agents. Furthermore, targeting these pathways, perhaps via combination with galectin-1 or Axl inhibitors may provide additional strategies for the treatment of resistant tumours. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: acquired resistance ; breast cancer ; EMT ; HER2 ; proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Thierry Le Bihan, SynthSys University of Edinburgh, N/A
Submitting User: ccms

Publications

Creedon H, Gómez-Cuadrado L, Tarnauskait? Ž, Balla J, Canel M, MacLeod KG, Serrels B, Fraser C, Unciti-Broceta A, Tracey N, Le Bihan T, Klinowska T, Sims AH, Byron A, Brunton VG.
Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy.
Oncotarget. 2016 Mar 8;7(10):11539-52.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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