MassIVE MSV000086108

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Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans

Description

Proteomic analysis of serum IgG antibody repertoire against influenza vaccine H1 (H1N1 A/California/7/2009) and H3 (H3N2 A/Texas/50/2012) in young, middle-aged, and elderly donors vaccinated with Fluzone 2013-14/14-15. Dataset consists of peak-response (days 21-28 post-vaccination) serum IgG samples eluted by affinity chromatography against H1 and H3 vaccine or hemagglutinin and the flow-throughs. [doi:10.25345/C55T9R] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: serum antibody repertoire ; Ig-Seq ; influenza ; vaccination ; immunoglobulin

Contact

Principal Investigators:
(in alphabetical order)
George Georgiou, University of Texas at Austin, USA
Submitting User: jj33569

Publications

Jung J, Mundle ST, Ustyugova IV, Horton AP, Boutz DR, Pougatcheva S, Prabakaran P, McDaniel JR, King GR, Park D, Person MD, Ye C, Tan B, Tanno Y, Kim JE, Curtis NC, DiNapoli J, Delagrave S, Ross TM, Ippolito GC, Kleanthous H, Lee J, Georgiou G.
Influenza vaccination in the elderly boosts antibodies against conserved viral proteins and egg-produced glycans.
J Clin Invest.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.