MassIVE MSV000098032

Complete Public PXD064413

Markers of neutrophil degranulation in the lung microenvironment linked to idiopathic pulmonary fibrosis severity and survival

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Description

Idiopathic pulmonary fibrosis (IPF) leads to progressive loss of lung function and mortality. Understanding mechanisms and markers of lung injury in IPF is paramount to improving outcomes for these patients. Despite the lack of systemic involvement in IPF, many analyses focus on identifying circulating prognostic markers. Using a proteomic discovery method followed by ELISA confirmation in multiple cohorts we explored novel markers of IPF survival in bronchoalveolar lavage fluid (BALF) [doi:10.25345/C5GM8219Q] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Idiopathic pulmonary fibrosis ; bronchoalveolar lavage fluid ; label free proteomics ; neutrophil degranulation ; DatasetType:Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Scott Matson, University of Kansas Medical Center, USA
Submitting User: KUMC_Prot

Publications

Scott M Matson, Linh T Ngo, Yui Sugawara, Veani Fernando, Claudia Lugo, Angela Kaczorowski-Worthley, Imaan Azeem, Alexis Harrison, Alex Alsup, Emily Schueddig, Devin Koestler, Michaella J Rekowski, Paul J Wolters, Joyce S Lee, Michael P Washburn, Joshua J Solomon, M Kristen Demoruelle.
Neutrophil degranulation in the lung microenvironment linked to idiopathic pulmonary fibrosis severity and survival.
iScience. 2025 Nov 19;29(1):114125. doi: 10.1016/j.isci.2025.114125.

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