Mutations in Ubiquilins, UBQLN2, and UBQLN4 cause familial ALS. The role of UBQLNs in proteasomal degradation is well established but their role in autophagy-lysosomal clearance is poorly defined. Here, we performed Ubqn-GFP pull down from fly samples to find Ubqn binding partners.
[doi:10.25345/C5K02J]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Ubiquilin
Principal Investigators: (in alphabetical order) |
Hugo J. Bellen, Baylor College of Medicine, United States |
Submitting User: | syjung |
?entürk M, Lin G, Zuo Z, Mao D, Watson E, Mikos AG, Bellen HJ.
Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
Nat. Cell Biol. 2019 Mar;21(3):384-396. Epub 2019 Feb 25.
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