MassIVE MSV000083259

Partial Public PXD012104

Ubiquilin interactomes from Fly

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Description

Mutations in Ubiquilins, UBQLN2, and UBQLN4 cause familial ALS. The role of UBQLNs in proteasomal degradation is well established but their role in autophagy-lysosomal clearance is poorly defined. Here, we performed Ubqn-GFP pull down from fly samples to find Ubqn binding partners. [doi:10.25345/C5K02J] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Ubiquilin

Contact

Principal Investigators:
(in alphabetical order) 		Hugo J. Bellen, Baylor College of Medicine, United States
Submitting User: syjung

Publications

?entürk M, Lin G, Zuo Z, Mao D, Watson E, Mikos AG, Bellen HJ.
Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
Nat. Cell Biol. 2019 Mar;21(3):384-396. Epub 2019 Feb 25.

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