MassIVE MSV000099309

Partial Public PXD068958

Urinary Proteomic Profiling in Pregnancies Affected by Fetal Aneuploidies

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Description

Mass spectrometry-based proteomics has greatly advanced our understanding of biological processes across diverse fields, including disease and oncology. Despite this progress, the maternal-fetal interface, particularly in the context of fetal aneuploidy, remains underexplored. This study addressed this gap by performing an exploratory, label-free mass spectrometry-based proteomic analysis of maternal urine from 15 pregnancies with normal karyo-type and 9 with fetal aneuploidy. [doi:10.25345/C57H1F09Z] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: fetal aneuploidy ; urine proteomics ; label-free proteomics ; DatasetType:Proteomics

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Principal Investigators:
(in alphabetical order) 		Iuga Cristina-Adela, MEDFUTURE Research Center for Advanced Medicine, Romania
Submitting User: ioanapralea
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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
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