MassIVE MSV000085447

Partial Public

Mitovesicles are mitochondria derived extracellular vesicles altered by aging and disease

Description

Mitochondrial dysfunction is an established hallmark of aging and neural degenerative disorders such as Down syndrome and Alzheimer disease. Employing a high resolution density gradient on extracellular vesicles isolated from murine and human Down syndrome and diploid control brains, we identify and characterize a formerly unknown population of extracellular vesicles containing multiple mitochondrial markers that are distinct from the previously described EVs subtypes, microvesicles and exosomes. We term these mitochondria-derived EVs mitovesicles. We show that brain mitovesicle levels and cargo are tightly regulated under normal conditions and are altered during pathophysiological processes in which mitochondrial dysfunction occurs, suggesting that mitovesicles are a previously unrecognized player in mitochondria quality control and may have an active role in the intercellular tissue response to oxidative stress. [doi:10.25345/C5Q99J] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Mitochondria ; Alzheimer's Disease ; Down Syndrome ; Mitovesicles ; Extracellular Vesicles

Contact

Principal Investigators:
(in alphabetical order)
Thomas A. Neubert, New York University School of Medicine, USA
Submitting User: hbromage
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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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