MassIVE MSV000098111

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Supporting raw MS data for paper by Yi S. et al (2025), titled "Activity-based probes and chemical proteomics uncover the biological impact of targeting HMGCS1 in the mevalonate pathway".

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Description

Supporting raw MS data for paper (doi:10.1016/j.jbc.2025.110660) by Yi S., et al (2025), titled "Activity-based probes and chemical proteomics uncover the biological impact of targeting HMGCS1 in the mevalonate pathway.". Index of MS files and labels Supplementary Table 1 - HEK293T - Affinity-purification (LS-2-53 | Unimod:35; 737; 4 | 126 - HG-pretreated;127n - HG-pretreated;128c - HG-pretreated;129n - DMSO-pretreated;130c - DMSO-pretreated;131n - DMSO-pretreated). Supplementary Table 2 - HCT116 - Proteome (LS-2-15 | Unimod:35; 2016; 4 | 126 - DMSO treated;127n - DMSO treated;127c - DMSO treated;128n - DMSO treated;128c - dTAGv1 treated;129n - dTAGv1 treated;129c - dTAGv1 treated;130n - dTAGv1 treated;130c - HG treated;131n - HG treated;131c - HG treated;132n - HG treated;132c - Simvastatin treated;133n - Simvastatin treated;133c - Simvastatin treated;134n - Simvastatin treated). [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: HMGCS1 ; TMT ; TMTpro ; DatasetType:Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Alban Ordureau, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, USA
Submitting User: aordureau

Publications

Yi SA, Sun L, Rao Y, Ordureau A, Lewis JS, An H.
Activity-based probes and chemical proteomics uncover the biological impact of targeting HMGCS1 in the mevalonate pathway.
J Biol Chem. Epub 2025 Sep 3.

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