MassIVE MSV000088036

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GNPS - Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.) mediated neuroprotection in a rotenone-induced cellular model of Parkinsons disease

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Description

In the present study we carried out global and targeted metabolomics of differentiated IMR32 cells to study the neuroprotective mechanism of Yashtimadhu (Glycyrrhiza glabra L.) in rotenone induced cellular model of parkinsons disease. Our mass spectrometry data highlighted 2403 and 2934 aligned metabolites from the positive and negative modes respectively. Among the aligned metabolites, 756 metabolites from positive and 731 metabolites from negative polarity, were mapped to a known metabolite, and the others remained unassigned. A total of 1,102 non-redundant metabolites from the positive and negative modes were assigned. [doi:10.25345/C5583Z] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Complementary and alternative medicine ; metabolic stress ; oxidative stress ; complex-I inhibition

Contact

Principal Investigators:
(in alphabetical order) 		T. S. Keshava Prasad, Yenepoya Research Centre, Yenepoya (Deemed to be University), India
Submitting User: tsk_prasad

Publications

Karthikkeyan G, Behera SK, Upadhyay SS, Pervaje R, Prasad TSK, Modi PK.
Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)-mediated neuroprotection in a rotenone-induced cellular model of Parkinson's disease by restoring the mTORC1-AMPK1 axis in autophagic regulation.
Phytother Res. 2022 May;36(5):2207-2222. Epub 2022 Mar 20.

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GNPS content goes here (MSV000088036 [task=6ab00a1b1d9f42e78b9416221f168631])
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