MassIVE MSV000086599

Partial Public PXD023150

Quantitative proteomics identifies ML111 as a cell-cycle inhibitor

Description

We used quantitative mass spectrometry to analyze the effect of ML111 on the whole proteome of SK-N-MC cells. Results: ML111 treatment results in the accumulation of APC/C substrates suggesting that ML111 disrupts the cell cycle at or before the mitotic spindle assembly checkpoint. [doi:10.25345/C54N56] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Ewing sarcoma ; ML111 ; quantitative mass spectroscopy ; isobaric tag ; drug discovery

Contact

Principal Investigators:
(in alphabetical order)
Mark Leid, Oregon State University, USA
Submitting User: Walter_Vogel

Publications

Esfandiari Nazzaro E, Sabei FY, Vogel WK, Nazari M, Nicholson KS, Gafken PR, Taratula O, Taratula O, Davare MA, Leid M.
Discovery and Validation of a Compound to Target Ewing's Sarcoma.
Pharmaceutics. 2021, 13, 1553. Epub 2021 Sep 24.

Esfandiari Nazzaro, E.; Sabei, F.Y.; Vogel, W.K.; Nazari, M.; Nicholson, K.S.; Gafken, P.R.; Taratula, O.; Taratula, O.; Davare, M.A.; Leid, M.
Discovery and Validation of a Compound to Target Ewing’s Sarcoma.
Pharmaceutics 2021, 13 (in press).

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