MassIVE MSV000089696

Partial Public PXD034801

Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes

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Description

To investigate the role of the transient receptor potential channel vanilloid type 1 (TRPV1) channel in hepatic glucose metabolism, we performed proteomics analysis of the liver of C57Bl/6J (WT) and Trpv1 KO mice (n = 4 per group). Liver from Trpv1 KO mice showed significant proteomics changes consistent with enhanced glycogenolysis, as well as increased gluconeogenesis and inflammatory features. [doi:10.25345/C5VD6P84G] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Liver, Glucose metabolism, proteomics

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Principal Investigators:
(in alphabetical order) 		Jose Thalles Lacerda, University of Sao Paulo, Brazil
Maria Nathalia Moraes, Federal University of Sao Paulo, Brazil
Submitting User: jthalles
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